This usually means one of the following:
You need to reboot your PC
Your virus scanner has touched the file. You may need to white list/allow list the file in question (ISXEQ2.dll)
-> You may need to redownload the file afterwards.
The file got corrupt, and you need to redownload it (ISXEQ2.dll)
Innerspace will some times get "stuck" and refuse to load dlls, or specific dlls (I believe this is a registry problem with IgnoreFreedDll or something like that.. the easiest fix, is to install Innerspace over top of itself (don't have to uninstall first) and this seems to fix it.
Like always, I always recommend NEVER to install things to Program Files (x86), simply because of the crazy permission problems there it causes.