One step at a time.
What version is your innerspace? (hover over the cross hair by the cloak, it should say: 1.1# (Build ####). Fill in the # for us.
Do you have ISXEQ2 (Or ISXOgre) auto loading? If so, remove them from auto loading.
Does it crash when you load the game through innerspace with nothing auto loading?
If yes - Innerspace problem. If you get any error message, crash reports, anything at all, post it EXACTLY (copy paste if possible).
If no - continue
Load ISXEQ2 (ext isxeq2). Does it crash?
If yes - ISXEQ2 problem - If you get any error message, crash reports, anything at all, post it EXACTLY (copy paste if possible).
If no - continue
If you use ISXOgre, load it (ext isxogre). Does it crash?
If yes - ISXOgre problem - If you get any error message, crash reports, anything at all, post it EXACTLY (copy paste if possible).
If no - continue
Log into the game.
Did you crash while loading? If so, it could be numerous things. However lately it's a good possibility it is your UI. Reinstall it if needed.
If no - continue
If you made it into the game without crashing, then provide more information.