This is happening to me now as well, on all 3 of my PC's (they all vary to quite a degree, one quad core on xp32, one amd on xp32, one p4 running server2k3). It always does the first round of reactions but then will not do any durability or progress afterwards.
I sat on voice with my friend and his works without a problem. We even tried to compare our xml and script folders with WinMerge to look for any differences to no avail.
Pressing 1/2/3/etc on the keyboard while its running does work. Any ideas?
Edit: Tried complete reinstall of EQ2 (discs then 5hour patch) as well as complete reinstall of ISX and ISXEQ2 still to no avail.
This only started happening after there was talk of the craft events being changed to triggers. Is there any case that would prevent the triggers from working?